CONTROLLING RESISTANCE

		Moxifloxacin (Ocumox) also has better mutant prevention characteristics than other fluoroquinolones
		Moxifloxacin (Ocumox) has dual mechanism of action, which helps reduce the propensity for resistance
		Because of the decreased effectiveness, there is a need for new ophthalmic antibiotics with better gram positive coverage, especially against Streptococcus; increased efficacy against resistant organisms such as Staphylococcus and against atypical mycobacteria; and better penetration into the anterior chamber. Moxifloaxcin (Ocumox) exhibit these characteristics and is less likely than earlier-generation agents to be affected by genetic mutation or to select for resistance
		Resistance development is minimized with the fourth generation fluoroquinolones because of their dual mechanism of antibacterial action, and they also demonstrate activity in vitro against some species of atypical mycobacteria
		Gram positive bacteria are of primary concern when it comes to both cataract & refractive surgery because they cause the majority of post operative infections. Moxifloxacin (Ocumox) binds with gram positive bacteria at two different sites: (Topoisomerase II and IV). For this reason the new flouroquinolones can kill organisms that are resistant to earlier formulations